Primary Hyperoxaluria: A Comprehensive Review

Authors

  • Ebtehal Ben-Hamed Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Sara Kara Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Maisoona Alsaadi Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Manal Aboagela Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Nagat Alshohubi Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Ayaa Elabany Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Fatema Layas Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
  • Arij Mousa Public Health Department, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya

Keywords:

Primary Hyperoxaluria, Low Oxalate Diet, Primary Hyperoxaluria in Libya, Kidney Stones, Oxalate Metabolism, Genetic Mutations, Consanguineous marriage

Abstract

Hyperoxaluria is characterized by excessive urinary oxalate excretion, which eventually leads to calcium oxalate kidney stone formation and severe complications. Primary hyperoxaluria (PH) is a rare genetic disorder with subtypes PH1, PH2, and PH3, each caused by specific enzyme deficiencies leading to oxalate overproduction. Globally, type 1 hyperoxaluria is the most prevalent type, as well as in Libya and North Africa. PH1 is common due to inbreeding, which leads to more mutations. Effective management depends on prompt genetic diagnosis. Management options, including changes in food intake, pharmacotherapy, and organ replacement in extreme cases, have proven their reliability. Developments such as enzyme replacement therapy and gene therapy might be promising options for PH treatment. The suggested measurements aimed to achieve a prompt prevention of kidney stone formation and renal failure, and all the mentioned treatment options have been discussed in this paper.

 

 

Dimensions

Published

2025-04-21

How to Cite

Ebtehal Ben-Hamed, Sara Kara, Maisoona Alsaadi, Manal Aboagela, Nagat Alshohubi, Ayaa Elabany, Fatema Layas, & Arij Mousa. (2025). Primary Hyperoxaluria: A Comprehensive Review. North African Journal of Scientific Publishing, 3(2), 99–107. Retrieved from https://najsp.com/index.php/home/article/view/442

Issue

المجلد الثالث، العدد الثاني، (أبريل - يونيو) 2025

Section

محور العلوم التطبيقية والطبيعية
Copyright & Licensing
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This work is licensed under a Creative Commons Attribution 4.0 International License.