Formulation and Optimization of Film Forming System Containing Hydrocortisone Drug

Abstract

For the topical distribution of the medication hydrocortisone, the current effort aimed to create, characterize, and optimize In-Situ Film formulations including the following polymers in varying concentrations: hydroxypropylcellulose, ethylcelullose, and eudragite E100. Hydrocortisone was synthesized in an in-situ film-forming formulation employing HPC, EC, and Eudragite E100 at two concentrations of each polymer (5% and 8%, respectively). Water, ethyl alcohol, and poropylen glycol are used as solvents and plasticizers. Formulations were evaluated using a variety of characteristics, including viscosity, drug content, in vitro release drug, drying time, pH value, physical appearance, and external sickness. All formulations are visually appealing and transparent, except for F3 and F6, which are white in color.  The film-forming formulations exhibited a drying time of 2 to 3 minutes, which is deemed acceptable.  The pH value of all formulations was acceptable.  The viscosities of the F1, F2, and F3 formulas rose above those of F4, F5, and F6 at lower shear rates because the concentration of polymers in the first film-forming formulations was increased.  The hydrocortisone content ranged from (97.22±1.3 to 105.67±1.7).  The formulation that forms a film offers a good drug percentage content, rendering clinical delivery of the drug feasible. The rise in polymer concentration in film-forming formulations like F1, F2, and F3 led to lower release values compared to other formulations with lower polymer concentrations, such as F4, F5, and F6.  After three months, results for F4 and F5 showed no difference in pH value or drying time.  Moreover, after three months of storage, the viscosity value and drug content of the In-Situ films were successfully preserved.