The Impact of Parity on Insulin Sensitivity: A Case-Control Study Using HOMA-IR Analysis

Abstract

This study, conducted in 2024 at Misrata Medical Center, aimed to investigate the impact of parity on insulin sensitivity using the HOMA-IR analysis. The research included 102 participants, with ages ranging from 18 to 50 years. They were divided into two groups: a control group of 46 nulliparous women (women with no deliveries) and a patient group of 56 multiparous women (women with more than three deliveries). A significant positive correlation was identified between parity and HOMA-IR (r = 0.489^**, p < 0.01), indicating that higher parity is associated with increased insulin resistance. Nulliparous women exhibited the lowest HOMA index values, while multiparous women, particularly those with five or more deliveries, showed the highest values. Statistical analysis confirmed significant differences in insulin resistance among parity groups, emphasizing the need for further studies to explore underlying mechanisms and clinical implications.